Table 2 Patient criteria for genetic testing according to NCCN clinical practice guidelines in oncology v.1.2010 [21] for HBOC
From: TP53 p.R337H prevalence in a series of Brazilian hereditary breast cancer families
| Patient 1 | Patient 2 | Criteria |
|---|---|---|
| X | Personal history of breast cancer ≤ 45 years | |
| Personal history of two primary breast cancers, the first being diagnosed before 50 years of age | ||
| Personal history of breast cancer with age at diagnosis < 50 years with limited family history | ||
| X | Personal history of breast cancer ≤ 50 years with ≥ 1 relative with breast cancer ≤ 50 years and/or ≥ 1 relative with epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer at any age | |
| Personal history of triple-negative breast cancer, with age at diagnosis < 60 years | ||
| X | Personal history of breast cancer at any age, with ≥ 2 relatives with breast cancer and/or epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer at any age | |
| Personal history of breast cancer + Personal history of epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer |