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Table 3 Clinical criteria and frequencies of pathogenic MLH1/MSH2 variants in Pakistani study participants

From: Prevalence and spectrum of MLH1, MSH2, and MSH6 pathogenic germline variants in Pakistani colorectal cancer patients

Clinical diagnostic criteria N with pathogenic variants N (%) without pathogenic variants N (%) P a
HNPCC 9 5 (55.6) 4 (44.4) *** < 0.0001b, 0.2047c
suspected-HNPCC 20 5 (25.0) 15 (75.0) ***0.0001 d
non-HNPCC 183 2 (1.1) 181 (98.9)  
Total cases 212 12 (5.7) 200 (94.3)  
  1. P values marked in bold are statistically significant
  2. aFisher’s exact test
  3. bHNPCC vs. non-HNPCC
  4. cHNPCC vs. suspected-HNPCC
  5. dsuspected-HNPCC vs. non-HNPCC
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287